Prozac for anxiety and depression: Everything you need to know

Prozac for anxiety and depression: Everything you need to know

Reviewed by:
Sophia Monsour, DO
Chief Psychiatrist, Pennsylvania
at Talkiatry
February 2, 2024

Everyone feels nervous from time to time, especially in stressful situations. Prepping for a big exam, starting a new job, or balancing your finances can all be anxiety-inducing. But if your anxiety becomes persistent and affects your quality of life, it might be a sign that you’re struggling with an anxiety disorder and to reach out to a professional for help.  

Anxiety disorders are a class of mental health conditions that can interfere with everyday activities by affecting the way you think and feel, and affect about 31 percent of U.S. adults. Fortunately, there are treatment options available to minimize symptoms and manage anxiety. If your doctor diagnoses you with an anxiety disorder, they’ll give you a personalized treatment plan that fits your specific symptoms. One of the most common ways anxiety disorders are treated is with medication, like Prozac.  

This article will walk you through Prozac’s efficacy, potential side effects, and its role in anxiety treatment.

What is Prozac and how does it work?

Prozac is the brand name for fluoxetine, a type of medication that belongs to a category of drugs called selective serotonin reuptake inhibitors (SSRIs) that are commonly prescribed to treat various mental health conditions, including anxiety disorders. SSRIs work by increasing levels of serotonin, a type of neurotransmitter, in the brain. Neurotransmitters are chemical messengers that send signals between neurons (nerve cells) in your brain and play a vital role in regulating a series of functions like your mood, emotions, and anxiety.  

This is important because low levels of serotonin have been linked to feelings of anxiety and depression. The reason is, serotonin helps your brain cells (neurons) talk to each other, and when there’s enough serotonin, it keeps the communication between the neurons running smoothly to balance your mood. But when serotonin levels are low, it disrupts the communication process between neurons, potentially causing you to feel anxious or nervous.  

So how do SSRIs help? When you ingest SSRIs like Prozac, it enters your bloodstream and eventually reaches your brain. Prozac then binds to a protein called the serotonin transporter to raise serotonin levels by blocking serotonin from being taken into the cells.  Plus, Prozac may help promote neuroplasticity, which is your brain's ability to reorganize itself by forming new connections between neurons. The thing is, your brain has an incredible ability to adapt to changes in neurotransmitter levels, and over time, your brain’s receptors and processes may adjust to these elevated serotonin levels. As a result, this can help your brain to adapt to anxiety-related changes.

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What conditions does Prozac treat?

While Prozac is primarily known as an antidepressant medication, used to treat major depressive disorder (MDD), it’s approved by the U.S. Food and Drug Administration (FDA) for treatment of various anxiety disorders, including:

  • Panic disorder: The involvement of recurrent panic attacks, which are sudden episodes of intense fear with physical symptoms of rapid heartbeat, trembling, and sweating. Prozac can help reduce the frequency and severity of panic attacks.
  • Obsessive-compulsive disorder (OCD): Prozac can help reduce symptoms of intrusive thoughts and compulsive behaviors from OCD.

Prozac is considered an effective anxiety medication and is often recommended as a first-line treatment strategy from prescribers. For people diagnosed with an anxiety disorder, Prozac helps ‘rewire’ the brain to respond more appropriately to stress or other triggers.

Off-label uses

Doctors sometimes prescribe Prozac off-label. An off-label prescription is when a medication is used to treat a condition that it wasn’t originally intended to treat. But if your doctor believes it can be an effective treatment strategy for another condition, they may prescribe it. Off-label uses of Prozac include:

Prozac can be a safe and effective part of your treatment plan, both for short and long-term use, when taken as directed by your doctor.    

Where can I get Prozac?

Similar to other antidepressants, Prozac is a prescription medication. A licensed prescriber, such as a psychiatrist, primary care doctor, or nurse practitioner can help you evaluate whether or not Prozac may be beneficial for you. There are a lot of factors to consider, such as your current symptoms, health history, family history, and whether or not you are taking other medications. A qualified mental health professional can help you navigate your treatment options so you can get back to feeling like yourself. If you’re experiencing any lingering symptoms of anxiety or changes in mood, reach out to a mental health professional like a psychiatrist.

Navigating the mental health care system may seem intimidating, but Talkiatry can help make it stress-free. You can see a psychiatrist from the comfort of home, and have your first appointment in just days. Take our free 10-minute online assessment to see if Talkiatry is right for you.  

What are the side effects of Prozac?

While Prozac is a widely used antidepressant to treat anxiety disorders and other mental health conditions, some people can experience side effects when taking it. Here’s a closer look.

Common side effects and management

  • Nausea
  • Drowsiness
  • Insomnia
  • Nervousness
  • Weight gain or loss
  • Diarrhea  
  • Bruising
  • Muscle weakness
  • Sexual dysfunction  

Not everyone will experience side effects, but if you do, they will likely start to appear within the first week or two of starting Prozac and will fade as your body adjusts to the medication. Always report any new or worsening symptoms to your prescribing doctor, even if what you’re feeling is mild. Your doctor may want to adjust your dose or medication.  

Certain medications or supplements can also increase your risk for certain side effects so be sure to let your doctor know if you are taking other medications, vitamins, or supplements.  

Prozac is an approved antidepressant for children 8 and older. It’s usually well-tolerated in children, but some children may experience increased irritability or impulsiveness. If they experience any persistent side effects, it’s important to reach out to their doctor immediately.  

Serious side effects and precautions

It’s important to note to always follow your prescribed dose when taking Prozac. You shouldn’t ever take more than what’s prescribed, which can increase the risk of unwanted – and serious side effects. Though not common, some people can experience serious side effects, such as:

  • New or onset suicidal ideation While rare, there may be an increased risk for suicidal thoughts and behavior.  
  • Serotonin syndrome: This can occur when too much serotonin builds up from medications like Prozac or other SSRIs. Symptoms can appear as feeling restless, confused, racing heart, trembling, or sweating. If untreated, serotonin syndrome can become life-threatening.
  • Allergic reactions: An allergy to Prozac can appear in the form of hives, rash, swelling of the face and/or throat, and difficulty breathing.  

If at any time while taking Prozac you’re noticing symptoms – whether it’s when you’re just starting or even if you’ve been taking it for a while, it’s important to reach out to your doctor right away.  

Comparing Prozac to other medications

Antidepressants can have varying effects for different people. And while some people might respond well to Prozac, others might not find it as effective. So it’s important to work with your doctor and to find the right one that works for you – this may require some trial and error as well.

Other SSRIs

Besides Prozac, other commonly prescribed SSRIs to treat anxiety disorders include Zoloft and Paxil.  their effects of alleviating symptoms may start quicker than Prozac but last for a shorter period. The benefit of Prozac is that it generally stays in your system longer and tends to be more forgiving with fewer withdrawal symptoms if you ever miss a dose.


Another class of antidepressants are Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), like Cymbalta, which are also commonly used to treat anxiety disorders and depression. Not only do they increase serotonin, like SSRIs, but they also increase levels of norepinephrine, a neurotransmitter that regulates your mood and stress response.  

TCAs and MAOIs

Tricyclic antidepressants (TCAs) is an antidepressant used to treat a wide-range of depressive symptoms, but can also be effective in treating certain anxiety disorders like OCD, GAD, or social phobia. TCA’s tend to come with a higher risk of side effects than other types of medications so they are usually only prescribed if people don’t respond to other types of treatment.  

Monoamine oxidase inhibitors (MAOIs) can be an effective treatment plan for depression and anxiety, particularly in cases where other antidepressants have been ineffective. They work by blocking the action of monoamine oxidase enzymes, which break down neurotransmitters like norepinephrine. However, due to higher risk of drug interactions compared to other medications, MAOIs are often only used as a second-line of treatment.

Special considerations when taking Prozac

When it comes to taking Prozac, it's crucial to consider special cases and take into account the unique circumstances of certain individuals.

Safety considerations for pregnant and breastfeeding individuals

If you’re struggling with a mental health condition like anxiety or depression while pregnant or breastfeeding, reach out to a mental health professional to consult safe treatment options and whether medications like Prozac might be right for you. While Prozac is considered generally safe for most, pregnant and breastfeeding individuals may require closer monitoring or adjustments in the dosage of Prozac.  

  • Pregnant: There are some complications reported when taking Prozac throughout the third trimester like preterm delivery.
  • Breastfeeding: Prozac is not recommended for people breastfeeding; a small number of cases report irritability, vomiting, diarrhea, and poor sleep for breastfed babies when exposed to fluoxetine.  

Pre-existing medical conditions

If you have a pre-existing medical condition, it's especially important to consult with a healthcare provider before starting Prozac or any other medication. Your healthcare provider can evaluate your medical history, current health status, and the potential interactions between Prozac and any other medications you might be taking. Prozac may not be recommended for you if you have certain medical conditions like:  

  • Cardiovascular conditions: Prozac can have effects on heart function, and people with a history of conditions like heart disease, arrhythmias, or a recent heart attack, may need special monitoring.
  • Hepatic conditions: People with liver cirrhosis may have a harder time in the clearance of the medication decreases and is not recommended.
  • Hypertension: The use of Prozac for those with hypertension (high blood pressure) should be carefully considered and monitored by a healthcare provider since Prozac can have effects on blood pressure.

Should I take Prozac for my anxiety?

Prozac is a widely used antidepressant that offers life-changing benefits to help treat various anxiety disorders and other mental health conditions. As an SSRIs, Prozac influences your serotonin levels to improve mood and minimize anxiety symptoms. If you’re struggling with anxiety that impacts your quality of life, reach out to a mental health professional to discuss whether Prozac may be a good option for your treatment plan.

With Talkiatry, you can see a psychiatrist from the comfort of your home, and you can schedule your first appointment in a matter of days. To get started, take our free online assessment, to see if Talkiatry is right for you and get matched with a psychiatrist.  

Talkiatry is a national psychiatry practice that provides in-network, virtual care. Co-founded by a patient and a triple-board-certified psychiatrist, Talkiatry has over 300 doctors, 60 insurance partners, and first visits available in days. We treat patients with anxiety disorders, depression, bipolar disorder, ADHD, and more.

The information in this article is for informational and educational purposes only and should never be substituted for medical advice, diagnoses, or treatment. If you or someone you know may be in danger, call 911 or the National Suicide and Crisis Lifeline at 988 right away.

Dr. Sophia Monsour holds the position of Chief Psychiatrist for Pennsylvania at Talkiatry. After completing residency in 2013 at Albany Medical Center, she has spent the past 9 years fulfilling her passion for integrated and specialty care for adults suffering from mental illness. Her years of experience has included working as an integrated care Psychiatrist at a community health center, a medical director of a Partial Hospital and Intensive Outpatient Program (PHP/IOP), and also working for an Assertive Community Treatment Team (ACT) specializing in the Serious Mentally Ill (SMI) population.

Most recently, she has been serving our veterans as the Outpatient Section Chief, Primary/Mental Health Integration Medical Director and Resident/Medical Student Coordinator at VA Pittsburgh. Dr. Monsour has an approachable style when treating individuals who suffer from various diagnoses, especially those with prior trauma. She provides supportive psychotherapy and at times uses psychodynamic therapy skills to address her patient’s current stressors and to identify the root cause of their ailment. She believes in a holistic approach and utilizes mindfulness as a technique along with medication management.

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