Talkiatry Medication Guide
Full evaluations and ongoing medication management from licensed doctors and clinicians.*
*[Treatment is always prescribed at the discretion and care guidance of a Talkiatry psychiatrist or PMHNP.] [Placeholder for legal language about controlled substances.]
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Commonly prescribed for:
- Bipolar disorder (especially bipolar depression)
- Seizure disorders
- Sometimes used off-label for mood instability
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- Stabilizes overactive nerve signaling. Lamotrigine helps regulate electrical activity in the brain by affecting sodium channels in brain cells.
- Reduces excess glutamate release. Glutamate is a stimulating neurotransmitter, and lowering its activity may help prevent extreme mood shifts and seizures.
- Helps stabilize mood over time. These effects can reduce depressive episodes and help maintain more consistent mood in people with bipolar disorder.
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- It must be started slowly. Doctors gradually increase the dose over several weeks to reduce the risk of certain side effects.
- Watch for new rashes. A rare but serious skin reaction can occur, so any new rash should be reported to your clinician right away.
- It helps prevent mood episodes. Lamotrigine is especially helpful for preventing bipolar depression, though it’s less effective for treating acute mania.
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How it works
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Lamotirigine is a commonly used medication for managing mood symptoms because it is generally well tolerated and has fewer side effects than other mood stabilizing medications. We monitor closely for a rash because it can be serious.
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*Based on patient’s responses to PHQ-8 or GAD-7 health questionnaires from 1/24-9/25.

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